Articles Tagged With:
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Neurofilament Light Chain: Differentiating bvFTD from Psychiatric Disorders
Behavioral-variant frontotemporal dementia (bvFTD) can be difficult to distinguish from a primary mood disorder at the early stages of disease. Biological markers, such as serum or cerebrospinal fluid neurofilament light chain, can help to make a distinction between the disorders, but the test carries a high false-negative rate.
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Oligoclonal Bands: What Utility Do They Have Beyond Multiple Sclerosis?
This retrospective study found that while oligoclonal bands (OCB) remain a highly sensitive and specific marker for multiple sclerosis (MS), they have limited diagnostic utility for other autoimmune central nervous system disorders. The findings underscore that OCB testing should be reserved for suspected MS and interpreted cautiously outside the MS context.
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Proton Craniospinal Irradiation for Leptomeningeal Metastasis
Proton craniospinal irradiation (pCSI) demonstrated better overall survival and progression-free survival outcomes compared to involved-field radiotherapy (IFRT) for the treatment of leptomeningeal metastases in patients with non-small cell lung cancer and breast cancer.
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Acupuncture to Treat Low Back Pain in Older Adults
A multisite, three-arm, parallel-group randomized clinical trial of older adults in the United States with chronic low back pain found improvement in both pain and disability with the addition of acupuncture treatment compared to usual medical care alone.
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Infectious Disease Updates
Emerging Carbapenemase Resistance in Enterobacterales; Jamestown Canyon Virus Common in Northern Minnesota and Wisconsin
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Chikungunya in New York
On Aug. 21, 2025, a 60-year-old woman living in Nassau County on Long Island became ill with symptoms that were marked by severe joint pain involving her feet, ankles, knees, wrists, hands, and shoulders.
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Enterococcal Infections: Getting More Difficult to Treat
Increasing resistance among enterococci dictates the need for careful antibiotic choices, even in the absence of high-quality clinical data.
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The Expanding Venues of Histoplasmosis and Blastomycosis in the United States
The occurrence of new cases of both histoplasmosis and blastomycosis is increasing in the United States, including in areas not generally considered endemic.
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Recombinant Herpes Zoster Vaccine in a Medicare Population
Receipt of adjuvanted recombinant herpes zoster vaccine was effective in individuals older than 64 years of age and maintained its efficacy in immunocompromised individuals. Added benefit accrued from receipt of the second vaccine dose, even if its administration was delayed.
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Absence of Pleocytosis in Cerebrospinal Fluid Does Not Rule Out Encephalitis
A retrospective study that included 597 adults with encephalitis found 25.3% did not have pleocytosis in their cerebrospinal fluid, and 23.7% of those with HSV-1 encephalitis lacked pleocytosis on the initial lumbar puncture.